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Polarization of M1 and M2 Human Monocyte-Derived Cells and Analysis with Flow Cytometry upon Mycobacterium tuberculosis Infection
Published on: September 18, 2020
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Peripheral blood cellular dynamics during the progression of human tuberculosis
Shanshan Zhu1, Qiuchen Dai2,3, Kai Wang2,3
1State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, China. 230198597@seu.edu.cn.
Scientific Reports
|October 28, 2025
Summary
Early changes in peripheral blood immune cells, especially natural killer (NK) cells, signal tuberculosis (TB) progression. These biomarkers can help identify individuals needing preventive interventions for TB.
Area of Science:
- Immunology
- Infectious Diseases
- Genomics
Background:
- Tuberculosis (TB) is a significant global health issue.
- Peripheral blood immune cell composition offers insights into TB.
- Understanding immune dynamics is crucial for TB management.
Purpose of the Study:
- To analyze peripheral blood immune cell dynamics across the TB disease spectrum.
- To identify early immune biomarkers for TB progression.
- To explore factors influencing immune responses in TB.
Main Methods:
- Analysis of 43 global transcriptomic datasets.
- Inclusion of 5,902 peripheral blood samples.
- Examination of cellular dynamics from latent infection to active TB and treatment.
Main Results:
- Early TB progression showed reduced natural killer (NK) cells and increased monocytes.
- Subclinical TB exhibited further NK and B cell reductions with elevated monocytes.
- Active TB featured high monocytes/neutrophils and low lymphocytes; treatment led to normalization.
- Immune responses varied with TB burden, age, and HIV coinfection.
Conclusions:
- Peripheral blood immune cell shifts, particularly NK cell changes, are early indicators of TB progression.
- These early biomarkers may serve as targets for preventive TB interventions.
- Cellular dynamics provide a comprehensive view of TB pathogenesis and treatment response.
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