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Updated: Jan 14, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

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Association between aortic valve calcification and cardiovascular events in patients with chronic kidney disease

Saki Hayashida1, Naoki Haruyama1, Hiroyuki Hayashida2

  • 1Division of Nephrology, Department of Internal Medicine, NHO Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-Ku, Fukuoka, 810-8563, Japan.

Scientific Reports
|October 28, 2025
PubMed

Insights

Aortic valve calcification (AVC) significantly increases cardiovascular (CV) event risk in chronic kidney disease (CKD) patients. AVC assessment aids in predicting prognosis for this high-risk population.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Biology

Background:

  • Aortic valve calcification (AVC) association with cardiovascular (CV) events is debated, especially in chronic kidney disease (CKD) patients.
  • CKD patients face a higher burden of CV disease, necessitating better risk stratification.

Purpose of the Study:

  • To investigate the association between AVC and incident CV events in a prospective cohort of patients with CKD.
  • To determine if AVC serves as an independent predictor of CV events in the CKD population.

Main Methods:

  • Prospective enrollment of 1,279 CKD participants.
  • Utilized Cox proportional hazard models and propensity score-matched analysis.
  • Categorized participants based on the number of calcified aortic cusps (CACs).

Main Results:

  • During a median 2.9-year follow-up, 185 CV events occurred.
  • Higher CAC scores (one vs. none, two-three vs. none) were associated with significantly increased CV event risk (HRs 1.94 and 2.21, respectively).
  • Propensity score-matched analysis confirmed a higher CV event risk in patients with AVC compared to those without.

Conclusions:

  • Aortic valve calcification is an independent risk factor for cardiovascular events in patients with chronic kidney disease.
  • Assessing AVC provides valuable prognostic information for CKD patients.
  • Further research into mechanisms linking AVC and CV events in CKD is warranted.

Keywords:
Aortic valve calcificationCardiovascular eventChronic kidney diseasePropensity score matching

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