Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Control of naive T cell reactivity and peripheral tolerance by ascorbate and TET activity.

Science advances·2026

Same author

Active repression of muscle fate preserves neural lineage identity during cerebellum development.

bioRxiv : the preprint server for biology·2026

Same author

BRD4 recruitment desilences transcription without erasure or depletion of repressive chromatin.

bioRxiv : the preprint server for biology·2026

Same author

Multifold increase in spinal inhibitory cell types with emergence of limb movement.

Cell reports·2026

Same author

Exclusion of Notch from the contact site during efferocytosis restricts anticancer immunity.

Nature immunology·2026

Same author

Locus coeruleus norepinephrine neurons facilitate orbitofrontal cortex remapping and behavioral flexibility.

Cell reports·2025

Same journal

Connectomic evidence that ordered activity drives neuromuscular network formation.

Nature neuroscience·2026

Same journal

Noninvasive decoding of typed sentences from human brain activity.

Nature neuroscience·2026

Same journal

Striatal control of amygdalar acetylcholine release during salience-associated processing.

Nature neuroscience·2026

Same journal

Mitochondrial stress response drives microglial senescence.

Nature neuroscience·2026

Same journal

Conditioned accumbal dopamine transients forecast individual preference for drug versus natural rewards and compulsive behavior.

Nature neuroscience·2026

Same journal

The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.

Nature neuroscience·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 14, 2026

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

Published on: March 31, 2022

Author Correction: A single-vector intersectional AAV strategy for interrogating cellular diversity and brain

Alex C Hughes^1,2, Brittany G Pittman¹, Beisi Xu³

¹Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Nature Neuroscience

|October 28, 2025

Summary

No abstract available in PubMed .

More Related Videos

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Scalable Fluidic Injector Arrays for Viral Targeting of Intact 3-D Brain Circuits

Scalable Fluidic Injector Arrays for Viral Targeting of Intact 3-D Brain Circuits

Published on: January 21, 2010

Related Experiment Videos

Last Updated: Jan 14, 2026

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

Published on: March 31, 2022

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Scalable Fluidic Injector Arrays for Viral Targeting of Intact 3-D Brain Circuits

Scalable Fluidic Injector Arrays for Viral Targeting of Intact 3-D Brain Circuits

Published on: January 21, 2010