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Compression Post-Extravasation of Parenteral Iron May Reduce Skin Staining.
Malindi Georgia Haggett1, Phillip Bekhor2
1Department of Dermatology, Western Health, Melbourne, Australia.
The Australasian Journal of Dermatology
|October 28, 2025
Summary
Applying compression after intravenous iron therapy may reduce skin staining. This simple method could prevent or minimize the cosmetic damage caused by iron extravasation injuries, improving patient outcomes.
Area of Science:
- Dermatology
- Vascular Medicine
Background:
- Iron extravasation injuries are a complication of intravenous iron therapy.
- These injuries can lead to permanent cosmetic damage and significant patient distress.
- Current treatments for iron staining are limited, costly, and require multiple sessions.
Purpose of the Study:
- To investigate the potential of post-infusion compression to minimize cutaneous siderosis following iron extravasation.
- To present a case series illustrating the effects of compression on iron staining.
Main Methods:
- Observation of four cases of iron extravasation injuries presenting to a dermatology clinic.
- Application of compression via bandages or dressings post-intravenous iron infusion.
- Documentation of hyperpigmentation patterns and staining severity in relation to compression areas.
Main Results:
- Distinct patterns of hyperpigmentation were observed in all four cases.
- Areas subjected to compression showed reduced iron staining compared to uncompressed areas.
- Compression appeared to reduce or prevent the development of cutaneous siderosis.
Conclusions:
- Post-infusion compression may be a simple, safe, and effective measure to minimize cutaneous siderosis.
- Compression offers a potential strategy to reduce the cosmetic impact and patient distress associated with iron extravasation.
- This approach could improve patient outcomes by preventing or reducing permanent skin staining.
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