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Related Experiment Video

Updated: Jan 13, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Gout therapy updated.

Kate L McCarty¹, Angelo L Gaffo^2,3, Cesar Diaz-Torne⁴

¹Tinsley Harrison Internal Medicine Residency Program, University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 327, Birmingham, AL 35294, USA.

Therapeutic Advances in Musculoskeletal Disease

|October 28, 2025

Summary

This summary is machine-generated.

Gout, a painful inflammatory arthritis from urate crystals, is rising globally. Optimal management is challenging, requiring consideration of comorbidities and adherence to treatment targets.

Keywords:

crystalline arthritis gout

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Area of Science:

Rheumatology
Internal Medicine
Pharmacology

Background:

Gout is a prevalent inflammatory arthritis caused by monosodium urate crystal deposition, linked to hyperuricemia.
Increasing global incidence and prevalence of gout are reported, influenced by genetics, diet, lifestyle, and comorbidities like diabetes and hypertension.
Effective gout management is hindered by suboptimal treatment rates and patient adherence.

Purpose of the Study:

To review gout pathophysiology.
To discuss current and emerging pharmacological and nonpharmacological treatments for chronic gout, flares, and prophylaxis.
To highlight the importance of considering comorbidities in therapeutic selection.

Main Methods:

Literature review of gout pathophysiology.
Analysis of current pharmacological urate-lowering therapies (ULTs) including xanthine oxidase inhibitors, uricosurics, and uricase.
Review of treatments for gout flares and prophylactic measures, including novel agents and nonpharmacological interventions.

Main Results:

Optimal chronic gout management involves a "treat to target" strategy aiming for serum urate levels ≤6 mg/dL.
Initiating ULTs with prophylaxis is recommended to mitigate flare risk.
Current flare treatments include NSAIDs, glucocorticoids, colchicine, and IL-1 antagonists; novel therapies are emerging.

Conclusions:

Gout management remains complex, necessitating a comprehensive approach that includes treating comorbidities and improving patient adherence.
Newer pharmacologic agents targeting urate reduction and inflammation offer promising advancements for chronic gout and flares.
Addressing diagnostic and provider adherence barriers is crucial for improving global gout care standards.