Sonographic Predictors and Outcomes of Second-Dose Misoprostol in Early Pregnancy Loss

Misoprostol is a preferred medical agent for managing early pregnancy loss. However, the optimal protocol, particularly repeat dosing, remains a topic of debate.

To evaluate the effectiveness of a second dose of misoprostol in women with incomplete uterine evacuation after the first dose, and to examine sonographic findings and demographic data to identify factors associated with successful treatment.

Retrospective descriptive study of electronic medical records from a tertiary university-affiliated hospital. We identified women who had early pregnancy loss and received a second dose of misoprostol vaginally after an incomplete response to the first dose.

A second dose of misoprostol achieved a 49% success rate for uterine evacuation without surgical intervention. Demographic and obstetric characteristics were similar in both the intervention and non-intervention groups; 44% of delayed miscarriages and 49% of anembryonic pregnancies with an intact sac persisted after the second dose (p<0.001). Delayed miscarriage and anembryonic pregnancy after the first dose significantly increased the odds of surgical intervention (delayed miscarriage: odds ratio (OR) 4.138, 95% confidence interval (CI) 1.513-11.317; anembryonic pregnancy: OR 2.921, 95% CI 1.349-6.326).

A second dose of misoprostol offers effective care. Sonographic results after the first dose help forecast the need for surgical intervention.