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Anemia as a Predictor of Mortality in Indian Patients With Cerebral Venous Thrombosis: A Six-Month Follow-Up Study

Atlanta Borah1, Jayaram Saibaba2, Rupendra Nath Saha1

  • 1Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

The Neurohospitalist
|October 28, 2025
PubMed

Insights

Anemia affects nearly half of cerebral venous thrombosis (CVT) patients, increasing their risk of poor outcomes and mortality. Early detection and management of anemia in CVT cases are crucial for improving patient prognosis.

Area of Science:

  • Neurology
  • Hematology
  • Internal Medicine

Background:

  • Cerebral venous thrombosis (CVT) is a serious neurological condition.
  • Anemia has been linked to adverse outcomes in various medical conditions.
  • Limited Indian data exists on the association between anemia and CVT outcomes.

Purpose of the Study:

  • To investigate the frequency and types of anemia in Indian patients with CVT.
  • To determine the association between anemia and clinical outcomes (mortality and poor functional status) at 6 months post-CVT.
  • To provide data on anemia in CVT from an Indian population.

Main Methods:

  • An ambispective, observational study involving 203 CVT patients.
  • Anemia diagnosis based on World Health Organization (WHO) criteria.
  • Outcomes assessed at 6 months included mortality and modified Rankin Scale (mRS) scores (3-6 for poor outcome).
  • Binary logistic regression was used to analyze the association between anemia and outcomes, adjusting for confounders.

Main Results:

  • Anemia was present in 47% of CVT patients, with microcytic and iron-deficiency anemia being the most common types.
  • Anemic patients had significantly higher rates of poor outcome (38% vs 23%) and mortality (34% vs 20%) at 6 months compared to non-anemic patients.
  • After adjusting for confounders, anemia independently predicted a higher risk of poor outcome (aOR 4.3) and mortality (aOR 5.2).

Conclusions:

  • Anemia is a frequent comorbidity in patients with cerebral venous thrombosis.
  • Admission anemia is significantly associated with increased mortality and poor functional outcomes in CVT patients.
  • These findings highlight the importance of evaluating and managing anemia in CVT management strategies.
Abstract

Keywords:
Cerebral venous thrombosisiron deficiency anemiamodified Rankin Scale (mRS)prognostic factorstransferrin saturation

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