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Diagnostic and Predictive Utility of Plasma Phosphoethanolamine Levels in Depressive Disorder: A Naturalistic
Noriyuki Kawamura1, Akinori Nakata2, Tsuyoto Harada1
1Kawamura Clinic for General Practice, Gyouki-Kai Medical Corporation, Tokyo, Japan.
Objectives:
Plasma phosphoethanolamine (PEA) has been proposed as a potential biomarker for depressive disorder. To further assess its diagnostic utility and relevance across psychiatric conditions, we conducted a larger observational study in a psychiatric primary care setting.
Methods:
Between 2013 and 2020, 576 patients underwent DSM-5-based psychiatric assessments. Plasma PEA levels were measured in 295 patients with depressive disorders, 264 with other psychiatric disorders, and 17 with physical illnesses.
Results:
PEA demonstrated moderate or high diagnostic accuracy for depressive disorder (AUC = 0.81, 95% CI: 0.78-0.85). Lower PEA levels were significantly associated with depression (OR = 16.30, p < 0.001).
Conclusions:
These findings suggest that plasma PEA concentration may serve as a useful biomarker for depressive disorder. Further studies are warranted to explore its potential relationship with white matter pathology in psychiatric conditions.
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