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Modularly Designed Transformable Peptides for Morphological Control and Biomedical Applications
Si Sun1, Jianli Zuo2,3, Yu Zuo1
1National Engineering Research Center of Immunological Products, Third Military Medical University, 30 Gaotanyan Zheng Street, Shapingba District, Chongqing, 400038, China.
Chembiochem : a European Journal of Chemical Biology
|October 28, 2025
Summary
Transformable peptides self-assemble into nanostructures for targeted disease treatment. These adaptable biomaterials show promise for advancing clinical applications in diagnostics and therapeutics.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Chemical Biology
Background:
- Transformable peptides exhibit unique structural tunability and modularity.
- They self-assemble into diverse nanostructures with tunable physicochemical properties.
- Research is progressing towards clinical translation of self-assembling peptides.
Purpose of the Study:
- To systematically review peptide building blocks and self-assembly mechanisms.
- To explore factors influencing nanostructure formation and transformation.
- To highlight biomedical applications of transformable peptide nanostructures.
Main Methods:
- Review of molecular design principles for self-assembling peptides.
- Analysis of noncovalent interactions driving peptide self-assembly.
- Summary of key factors governing peptide nanostructure transformation.
Main Results:
- Peptide self-assembly is guided by intermolecular forces and molecular design.
- Diverse nanostructures arise from controlled peptide assembly.
- Transformable peptides offer precise targeting for disease intervention.
Conclusions:
- Transformable peptides are promising biomaterials for biomedicine.
- Their applications span disease imaging, cancer therapy, and antimicrobial treatments.
- These materials hold significant potential for clinical translation.
