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Updated: Jan 13, 2026

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
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Published on: December 23, 2020

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Convergent Evolution and Host-Limiting Impacts of SARS-CoV-2 Revealed by Cellular Experiments

Ting Zhang1, Ren-Rong Tian1, Fengyi Li2,3

  • 1State Key Laboratory of Genetic Evolution & Animal Models, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China.

Molecular Biology and Evolution
|October 28, 2025
PubMed
Summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves rapidly. This study shows host factors like Type I interferons (IFN-I) influence viral Spike protein mutations, impacting SARS-CoV-2 evolution.

Keywords:
SARS-CoV-2convergent evolutionhost-specific selective pressuresmultihost experimental systemspike protein

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