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Exploring the significance of gut microbiota in cardiovascular health

Shamima Akter1, Mayank Choubey2, Md Majedur Rahman3

  • 1Department of Endocrinology, Diabetes & Metabolism, Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Williamsville, NY, USA.

Acta Cardiologica
|October 28, 2025
PubMed

Insights

Gut dysbiosis, an imbalance in gut bacteria, significantly impacts cardiovascular disease (CVD) development. Understanding these gut microbiota links offers new avenues for CVD prevention and treatment.

Area of Science:

  • Microbiome research
  • Cardiovascular science
  • Gut health

Background:

  • Cardiovascular disease (CVD) is a leading cause of death globally.
  • Gut microbiota composition is increasingly linked to various health conditions.
  • Gut dysbiosis, an imbalance in gut bacteria, is associated with CVD development and progression.

Purpose of the Study:

  • To review the pivotal role of gut microbiota in cardiovascular well-being.
  • To explore the link between gut microbiota and CVD development.
  • To highlight the need for interdisciplinary approaches in understanding gut bacterial-mediated CVD mechanisms.

Main Methods:

  • Comprehensive literature review on gut microbiota and cardiovascular disease.
  • Analysis of host-microbial interactions in relation to CVD risk factors.
  • Exploration of potential microbiome-based preventive and therapeutic strategies.

Main Results:

  • Gut dysbiosis contributes to CVD risk factors like atherosclerosis, hypertension, and heart failure.
  • Imbalances in gut microbiota disrupt homeostatic processes crucial for cardiovascular health.
  • The gut microbiome influences the development and progression of cardiovascular diseases.

Conclusions:

  • Targeting gut microbiota presents innovative opportunities for CVD prevention and treatment.
  • An interdisciplinary approach is essential for developing precise, microbiome-based CVD strategies.
  • Further research into gut bacterial-mediated mechanisms can advance cardiovascular health.

Keywords:
Cardiovascular healthatherosclerosisdysbiosisgut microbiotamicrobiome

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