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A Study on the Influencing Factors of Chronic Cough Caused by Mycoplasma Pneumoniae
Menghong Sang1, Jiaojiao Wang2, Xiaoxiao Jiang3
1First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Objective:
The purpose of this study was to investigate the risk factors for chronic coughing in children diagnosed with mycoplasma pneumoniae pneumonia (MPP) and provide a reference for a foundation for clinical diagnosis and therapy.
Methods:
A retrospective analysis was conducted by gathering pertinent clinical data from children with MPP who were hospitalized in the First Affiliated Hospital of Zhengzhou University. Relevant clinical data were collected during their hospitalization. At least 4 weeks after discharge from the hospital, the children were followed up by telephone and outpatient clinic to determine whether they had developed chronic cough. The number of sequential courses of azithromycin and the duration of the out-of-hospital nebulizer treatment were recorded. Results 28 cases (14.9%) with chronic cough among the 188 children with MPP were included in the case group, while 160 cases (85.1%) were included in the control group. Age, C reactive protein (CRP), CT feature, Mycoplasma antibody titers, the number of sequential courses of azithromycin and the number of days of nebulization therapy in the case group were statistically different from those in the control group (p < 0.05). Through logistic regression analysis, we found that the history of atopic constitution, serum IgE levels, the number of sequential courses of azithromycin, and the number of days of nebulization therapy influenced chronic cough in MPP children. (p < 0.05).
Conclusion:
Our findings indicate a potential association between atopic constitution and the development of chronic cough in MPP children, and suggest that sequential azithromycin and nebulization therapy might help reduce the likelihood of chronic cough.
Insights
Children with Mycoplasma pneumoniae pneumonia (MPP) who have an atopic constitution may be at higher risk for chronic cough. Sequential azithromycin and nebulization therapy may help reduce this risk.
Area of Science:
- Pediatrics
- Infectious Diseases
- Respiratory Medicine
Background:
- Mycoplasma pneumoniae pneumonia (MPP) is a common childhood infection.
- Chronic cough is a potential complication of MPP.
- Identifying risk factors for chronic cough in MPP is crucial for effective management.
Purpose of the Study:
- To investigate risk factors for chronic cough in children with MPP.
- To provide a foundation for clinical diagnosis and therapy of MPP-associated chronic cough.
Main Methods:
- Retrospective analysis of clinical data from 188 children with MPP.
- Follow-up via telephone and outpatient clinic to assess for chronic cough (defined as >4 weeks post-discharge).
- Logistic regression analysis to identify influencing factors.
Main Results:
- 28 cases (14.9%) developed chronic cough.
- Significant differences observed in age, CRP, CT features, Mycoplasma antibody titers, azithromycin courses, and nebulization duration between chronic cough and control groups.
- Atopic constitution, serum IgE levels, azithromycin courses, and nebulization duration were identified as significant influencing factors for chronic cough.
Conclusions:
- Atopic constitution is a potential risk factor for developing chronic cough in children with MPP.
- Sequential azithromycin and nebulization therapy may decrease the incidence of chronic cough in MPP patients.
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