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The Evolving Role of In Vitro-In Vivo Correlation in Model-Informed Drug Development: A Multi-Stakeholder

Marylore Chenel1, Sylvain Fouliard2, Emma Hansson1

  • 1Pharmetheus AB, Uppsala, Sweden.

CPT: Pharmacometrics & Systems Pharmacology
|October 28, 2025
PubMed
Summary

Physiologically based biopharmaceutics modeling (PBBM) and in vitro-in vivo correlation (IVIVC) models are vital for predicting drug performance. This review explores challenges and opportunities for their enhanced application in pharmaceutical development and regulatory science.

Keywords:
biopharmaceuticsin vitro–in vivo correlationmodel informed drug developmentphysiologically based biopharmaceutics modelingphysiologically based pharmacokinetics

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