Reversible Chemistry for Cancer Therapy and Diagnosis

Area of Science:

• Materials Science
• Oncology
• Nanotechnology

Background:

• Reversible chemistry strategies dynamically respond to external and internal stimuli, offering unique advantages over irreversible methods in cancer treatment.
• These advantages include sustainable function, targeted delivery, and enhanced drug retention, crucial for effective cancer therapy and diagnosis.

Purpose of the Study:

• To comprehensively review reversible chemistry strategies for cancer therapy and imaging.
• To explore the utilization of multiscale materials for various reversible control mechanisms.
• To present applications, advantages, challenges, and clinical potential of these strategies.

Main Methods:

• Exploration of multiscale materials (molecular, nano, micro, macro) for reversible control.
• Analysis of control mechanisms including electronic transitions, isomerization, valence changes, morphology changes, and mechanical motion.
• Review of existing literature on applications, advantages, and challenges in cancer therapy and imaging.

Main Results:

• Reversible strategies enable on-demand control, deep tumor penetration, and long-term drug retention.
• Various reversible control mechanisms can be applied to multiscale materials for tailored therapeutic and diagnostic functions.
• Significant potential exists for clinical translation, though challenges remain.

Conclusions:

• Reversible chemistry provides a powerful platform for precise cancer treatment and early diagnosis.
• Multiscale materials and diverse control mechanisms offer versatile approaches for advanced cancer care.
• Further research and development are needed to overcome clinical challenges and fully realize the potential of these innovative strategies.