Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

472
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
472
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

532
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
532
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

820
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
820
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

921
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
921
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.4K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.4K
First Impression01:09

First Impression

179
First impressions play a crucial role in social perception, shaping how individuals assess others in professional, academic, and interpersonal contexts. Psychological research highlights the significance of cognitive biases, such as the primacy and recency effects, which influence how people interpret and recall information.The Primacy Effect and Cognitive AnchoringThe primacy effect describes the tendency for initial information to impact judgment disproportionately. When individuals encounter...
179

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

British Red Squirrels (<i>S. vulgaris</i>) With Leprosy Develop Skeletal Lesions.

Interdisciplinary perspectives on infectious diseases·2026
Same author

Altered hepatic metabolic landscape and insulin sensitivity in response to pulmonary tuberculosis.

PLoS pathogens·2024
Same author

A gut microbiota rheostat forecasts responsiveness to PD-L1 and VEGF blockade in mesothelioma.

Nature communications·2024
Same author

Balance between Protection and Pathogenic Response to Aerosol Challenge with <i>Mycobacterium tuberculosis</i> (Mtb) in Mice Vaccinated with TriFu64, a Fusion Consisting of Three Mtb Antigens.

Vaccines·2021
Same author

CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation.

Journal of immunology (Baltimore, Md. : 1950)·2020
Same author

Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation.

PLoS pathogens·2019
Same journal

Retraction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.

The Journal of experimental medicine·2026
Same journal

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.

The Journal of experimental medicine·2026
Same journal

Flawed translation triggers oncogenic B-T cell communication.

The Journal of experimental medicine·2026
Same journal

Correction: LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated.

The Journal of experimental medicine·2026
Same journal

Mechanobiology of inflammation: Pulling the strings of innate immunity.

The Journal of experimental medicine·2026
Same journal

Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis.

The Journal of experimental medicine·2026
See all related articles

Related Experiment Video

Updated: Jan 13, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.2K

First impressions count in TB.

Andrea M Cooper1

  • 1University of Leicester , Leicester, UK.

The Journal of Experimental Medicine
|October 28, 2025
PubMed
Summary
This summary is machine-generated.

Mycobacterium tuberculosis infection triggers immune responses that can hinder protective T cell interactions. Early control of type I interferon is crucial for preventing rapid disease progression.

More Related Videos

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

9.0K
Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.2K

Related Experiment Videos

Last Updated: Jan 13, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.2K
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

9.0K
Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.2K

Area of Science:

  • Immunology
  • Microbiology
  • Infectious Diseases

Background:

  • Mycobacterium tuberculosis (Mtb) infection is a major global health concern.
  • Type I interferons (IFNs) play a complex role in host defense against Mtb.
  • Neutrophil accumulation is a key feature of the early immune response to Mtb.

Purpose of the Study:

  • To investigate the role of type I IFN-mediated neutrophil accumulation in the early stages of Mtb infection.
  • To understand how neutrophil accumulation impacts T cell-macrophage interactions during Mtb infection.
  • To determine the significance of early type I IFN control in disease progression.

Main Methods:

  • The study likely involved in vitro or in vivo models of Mtb infection.
  • Analysis of immune cell populations, including neutrophils, CD4 T cells, and macrophages.
  • Measurement of type I IFN signaling pathways and their impact on immune cell function.

Main Results:

  • Mtb infection induces type I IFN production, leading to neutrophil recruitment.
  • Neutrophil accumulation restricts the crucial interaction between CD4 T cells and macrophages.
  • Failure to limit type I IFN signaling early in infection correlates with accelerated disease progression.

Conclusions:

  • Type I IFN-driven neutrophil accumulation acts as a mechanism that limits effective anti-Mtb immune responses.
  • Early modulation of type I IFN responses is critical for controlling Mtb infection and preventing rapid disease.
  • Targeting type I IFN pathways may offer therapeutic strategies for tuberculosis.