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Metronomic Chemotherapy: A Novel Approach in Cancer Treatment
Mangal Charan Murmu1, Hari Kumar Kuragayala2, Balaji Nagarajan3
1Professor Pediatric, Government Medical College, Sundargarh, Odisha, India.
Asian Pacific Journal of Cancer Prevention : APJCP
|October 28, 2025
Summary
Metronomic chemotherapy (MCT), a frequent low-dose regimen, offers reduced toxicity and improved tumor microenvironment modulation compared to traditional maximum tolerable dosing (MTD). This approach shows promise for enhanced cancer treatment outcomes.
Area of Science:
- Oncology
- Pharmacology
- Cancer Therapeutics
Background:
- Systemic chemotherapy traditionally uses maximum tolerable dosing (MTD), which causes significant toxicity.
- Metronomic chemotherapy (MCT) involves frequent, low-dose administration, offering distinct antiangiogenic and immunomodulatory benefits.
Purpose of the Study:
- To critically review the efficacy, safety, and integration of metronomic chemotherapy (MCT) into cancer care.
- To compare MCT with other modalities like immunotherapy and assess advancements in combination therapies and nanoformulations.
Main Methods:
- Comprehensive review of preclinical and clinical studies on metronomic chemotherapy.
- Evaluation of combination therapies, patient selection, resistance mechanisms, and nanoformulations.
- Comparative analysis of MCT against conventional MTD regimens and immunotherapy.
Main Results:
- MCT demonstrates reduced toxicity and improved patient tolerance compared to MTD regimens.
- Significant modulation of the tumor microenvironment and promising outcomes in various cancers, especially in combination therapies.
- Nanoformulations enhance MCT drug delivery and effectiveness; ongoing trials validate its clinical role.
Conclusions:
- Metronomic chemotherapy is a novel, effective oncology strategy with potential to overcome traditional chemotherapy limitations.
- Evidence supports broader adoption of MCT, with recommendations for optimizing its use in future cancer treatment protocols.
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