Temporal Evolution of the Profile of Patients Hospitalized with Heart Failure (2000-2022)

Teresa Seoane-Pillado1,2, Roi Suárez-Gil3, Sonia Pértega-Díaz1,2

  • 1Rheumatology and Health Research Group, Department of Health Sciences, Faculty of Health Sciences, University of La Coruña, Campus de Oza, 15006 La Coruña, Spain.

Clinics and Practice
|October 28, 2025
PubMed

Insights

Patient profiles for first-time congestive heart failure (CHF) admissions have shifted. Patients are now older, more frequently women, and present with more acute and chronic diseases, complicating management.

Area of Science:

  • Cardiology
  • Public Health
  • Geriatrics

Background:

  • Clinical characteristics of first-time congestive heart failure (CHF) patients may have evolved.
  • Understanding these changes is crucial for adapting healthcare strategies.

Purpose of the Study:

  • To analyze shifts in the clinical profiles of patients experiencing their first CHF episode over time.
  • To identify changes in patient demographics and comorbidities associated with initial CHF hospitalizations.

Main Methods:

  • Retrospective cohort study of 19,796 patients discharged with CHF diagnosis (2000-2022).
  • Utilized Minimum Basic Data Set-Hospital Data Set (MBDS) from a Spanish university hospital.
  • Employed the Apriori algorithm to analyze disease associations across five time periods.

Main Results:

  • Significant increases observed in mean patient age (75.9 to 81.6 years) and proportion of women (48.3% to 51.4%).
  • Marked rise in acute (1.1 to 2.7) and chronic (3.6 to 6.5) concomitant diseases per patient.
  • Increased complexity in disease associations leading to CHF, with a rise in median diagnoses per patient (3 to 7).

Conclusions:

  • Over two decades, patients admitted for their first CHF episode are older, predominantly female, and have more comorbidities.
  • These evolving patient characteristics present greater challenges for effective clinical management of heart failure.

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.8K
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
465
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
704
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
313
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
676
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
209