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Updated: Jan 13, 2026
04:49
Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase
Published on: February 11, 2022
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Elastin in the Pathogenesis of Abdominal Aortic Aneurysm
Dunpeng Cai1,2, Shi-You Chen1,2
1Departments of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.
Cells
|October 28, 2025
Summary
Abdominal aortic aneurysms (AAAs) involve elastin degradation, a key factor in aortic wall weakening and rupture. Targeting elastin offers promising diagnostic and therapeutic strategies for this life-threatening vascular disorder.
Area of Science:
- Vascular Biology
- Extracellular Matrix Biology
- Atherosclerosis Research
Background:
- Abdominal aortic aneurysms (AAAs) are life-threatening vascular conditions characterized by aortic dilation.
- Elastin degradation is a central pathological event in AAA development and rupture.
- Current understanding of elastin's role in AAA pathogenesis is evolving.
Purpose of the Study:
- To review recent discoveries on elastin biology in AAA.
- To emphasize molecular mechanisms of elastin degradation.
- To highlight the translational potential of elastin-centered interventions.
Main Methods:
- Review of current literature on elastin in AAA.
- Analysis of molecular mechanisms driving elastin degradation.
- Evaluation of diagnostic and therapeutic strategies targeting elastin.
Main Results:
- Elastin breakdown, fragmentation, and reduced content are hallmarks of human AAA.
- Elastin degradation is directly correlated with AAA initiation, expansion, and rupture risk in animal models.
- Elastin-derived peptides contribute to a cycle of inflammation and matrix degradation.
Conclusions:
- Elastin plays a pivotal role in AAA development, acting as a structural determinant.
- Biomarkers of elastin turnover and imaging techniques show potential for AAA risk stratification.
- Therapeutic strategies targeting elastin stabilization, cross-linking, and regeneration are promising for AAA treatment.
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