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Updated: Jan 13, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

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Right Ventricular Strain and Left Ventricular Strain Using Speckle Tracking Echocardiography-Independent Prognostic

Silvana-Elena Hojda1, Teodora Mocan1, Alexandra-Lucia Pop2

  • 1Department of Physiology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Number 1-3, Clinicilor Street, RO-400023 Cluj-Napoca, Romania.

Diseases (Basel, Switzerland)
|October 28, 2025
PubMed

Insights

NT-proBNP and 2D-STE measures predict advanced COPD stages. These biomarkers, including NT-proBNP, right and left ventricular strain, and pulmonary artery systolic pressure, are valuable for assessing COPD prognosis.

Area of Science:

  • Cardiology
  • Pulmonology
  • Biomarkers

Background:

  • Cardiovascular diseases are a leading cause of mortality in COPD patients.
  • Speckle-tracking echocardiography (2D-STE) assesses cardiac function but is understudied in COPD.
  • Investigating prognostic markers in COPD is crucial for patient management.

Purpose of the Study:

  • To explore the prognostic associations of 2D-STE echocardiography and laboratory biomarkers in COPD patients.
  • To identify predictors of advanced COPD stages.
  • To evaluate the role of NT-proBNP and oxidative stress markers in COPD.

Main Methods:

  • Included 70 participants: 55 COPD patients and 15 healthy controls.
  • Analyzed all four cardiac chambers using standard ultrasound and 2D-STE.
  • Measured NT-proBNP, reduced glutathione (GSH), GSH/GSSG ratio, malondialdehyde (MDA), and Caspase-3.

Main Results:

  • NT-proBNP > 325 pg/mL independently predicted advanced COPD (GOLD 3-4) (p=0.001).
  • 2D-STE revealed reduced RV and LV strain in COPD patients prior to LV ejection fraction changes.
  • RV/LV strain and PASP > 37.5 mmHg independently predicted advanced COPD (p=0.001).

Conclusions:

  • NT-proBNP is an independent biomarker for pulmonary hypertension and right heart overload in COPD.
  • NT-proBNP and RV/LV strain measurements predict advanced COPD stages (GOLD 3-4).
  • These findings highlight the prognostic value of echocardiographic and laboratory markers in COPD.
Abstract

Keywords:
Caspase-3GSHGSH/GSSG ratioLV GLSMDANT-proBNPRV4CSLRVFWSLoxidative stress

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