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Related Concept Videos

Flail Chest-II01:26

Flail Chest-II

516
Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
Assessment:
1. Clinical Evaluation:
History:
516

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Related Experiment Video

Updated: Jan 13, 2026

An Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps
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Modified Coronally Advanced Flaps: A Systematic Review and Meta-Analysis.

Miriana Gualtieri1, Annarita Signoriello1, Alessia Pardo1

  • 1Dentistry and Maxillo-Facial Surgery Unit, Department of Surgery, Dentistry, Paediatrics and Gynaecology (DIPSCOMI), University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy.

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|October 28, 2025
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Subepithelial connective tissue graft (sCTG) combined with Modified Coronally Advanced Flap (mCAF) surgery shows superior root coverage and keratinized tissue gain for gingival recession defects in the short-to-medium term. Further long-term studies are needed for other biomaterials.

Keywords:
connective tissue graftsgingival recessionsmucogingival surgeryxenogeneic grafts

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Area of Science:

  • Periodontology
  • Regenerative Dentistry
  • Oral Plastic Surgery

Background:

  • Gingival recession (GR) involves apical displacement of the gingival margin from the cemento-enamel junction, exposing root surfaces.
  • Root coverage periodontal plastic surgery (RCPPS), particularly Modified Coronally Advanced Flap (mCAF) with an envelope design, is effective for GR.
  • Biomaterials are increasingly used as adjuncts to mCAF for treating multiple adjacent GR (MAGR) defects.

Purpose of the Study:

  • To systematically review and compare the efficacy of various mCAF adjunctive techniques for treating MAGR defects.
  • To evaluate outcomes including root coverage (RC), esthetic results, and keratinized tissue (KT) augmentation.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials (RCTs) published between 2013-2025.
  • Studies focused on mCAF adjunctive techniques for MAGR defects with at least 6-month follow-up and ≥5 patients.
  • Databases searched: PubMed, Scopus, Web of Science, Cinahl Complete. Risk of bias assessed using RoB 2 Tool; evidence certainty evaluated with GRADEPro GDT.

Main Results:

  • Subepithelial connective tissue graft (sCTG) combined with mCAF showed statistically significant improvements in complete root coverage (CRC) and keratinized tissue width variation (ΔKTW) compared to other techniques.
  • High-level evidence indicated sCTG superiority over xenogeneic acellular dermal matrix (XADM) for CRC and ΔKTW.
  • Low-level evidence suggested sCTG achieved greater ΔKTW than collagen matrix (CM); no significant differences were found for esthetic outcomes (RES).

Conclusions:

  • The combination of sCTG with mCAF yields superior root coverage and keratinized tissue augmentation in the short-to-medium term.
  • Long-term efficacy of other mCAF adjunctive techniques requires further investigation due to study heterogeneity.
  • Additional long-term RCTs are necessary to validate the effectiveness of alternative biomaterials for MAGR defects.