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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Recent Progress in Polyphenol-Based Hydrogels for Wound Treatment and Monitoring.

Lulu Liu1, Wenrui Ma2, Junju Wang3

  • 1College of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.

Biosensors
|October 28, 2025
PubMed
Summary

Polyphenol-based hydrogels offer advanced wound healing and monitoring due to their biocompatibility and inherent therapeutic properties. This review explores their design, function, and potential in smart wound management systems.

Keywords:
hydrogelspolyphenolswound monitoringwound treatment

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Hydrogels are vital in biomedical applications due to tunable properties and biocompatibility.
  • Polyphenol-based hydrogels exhibit unique antibacterial, antioxidant, and anti-inflammatory characteristics.
  • These properties make them ideal for sophisticated wound treatment and monitoring.

Purpose of the Study:

  • To review recent advancements in polyphenol-based hydrogels for wound management and monitoring.
  • To emphasize innovative designs and integrated functionalities of these hydrogels.
  • To discuss future development potential in intelligent wound care.

Main Methods:

  • Overview of polyphenol structure, classification, and biological functions.
  • Discussion of construction methods, functions, and applications of representative polyphenol hydrogels.
  • Comprehensive summary of hydrogel applications in wound treatment and monitoring.

Main Results:

  • Polyphenol hydrogels show significant promise for wound healing and monitoring.
  • Innovative designs integrate multiple functionalities for enhanced therapeutic outcomes.
  • Recent developments include polyphenol hydrogel microneedles combined with AI for wound management.

Conclusions:

  • Polyphenol-based hydrogels are highly versatile for advanced wound care.
  • Further research into their design and preparation can optimize wound healing and intelligent management.
  • These materials hold substantial potential for future biomedical applications.