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Updated: May 12, 2026
Development of a Lateral Flow Immunochromatographic Strip for Rapid and Quantitative Detection of Small Molecule Compounds
Published on: November 13, 2021
MoS2 Nanoflower-Based Colorimetric and Photothermal Dual-Mode Lateral Flow Immunoassay for Highly Sensitive Detection
Meimei Xu1,2, Shuai Zhao2,3, Yusi Peng2,3
1Key Laboratory of Liquid Crystal Polymers Based Flexible Display Technology in National Petroleum and Chemical Industry, Xi'an Key Laboratory of Advanced Photo-Electronics Materials and Energy Conversion Device, Technological Institute of Materials & Energy Science (TIMES), Xijing University, Xi'an 710123, China.
Abstract:
The single colorimetric signal readout mode of traditional lateral flow immunoassay (LFIA), which relies on gold nanoparticles (Au NPs), is inadequate to meet the growing demand for detection in terms of sensitivity, accuracy, and flexibility. Herein, we reported a novel colorimetric and photothermal dual-mode LFIA (dLFIA) based on MoS2 nanoflowers for rapid detection of severe acute respiratory syndrome coronavirus 2 nucleocapsid protein (SARS-CoV-2 NP). Benefiting from the strong color-producing ability and near-infrared absorption of MoS2 nanoflowers, the visual limits of detection in colorimetric and photothermal modes were 1 and 0.1 ng/mL, respectively. The limit of detection for quantitative analysis in photothermal mode was 48 pg/mL, with a sensitivity about 10~208 times higher than that of Au NPs-LFIA. Additionally, the dLFIA strips exhibited excellent specificity, good reproducibility, and satisfactory recovery when detected the simulated nasal swab samples, possessing good application prospect.
