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Sociodemographic Factors, Intent-Uptake Disparities, and Nirsevimab Availability in Infant RSV Immunoprophylaxis

Brody J Lipsett1, Benjamin N Fogel1, Katherine E Shedlock1

  • 1Pediatrics, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033, USA.

Pediatric Reports
|October 28, 2025
PubMed

Insights

Sociodemographic factors influence respiratory syncytial virus (RSV) immunoprophylaxis uptake. Parental healthcare employment and out-of-home childcare were key predictors for nirsevimab intent and receipt, respectively.

Area of Science:

  • Pediatrics
  • Public Health
  • Immunology

Background:

  • Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization and bronchiolitis in the US.
  • New RSV prevention methods, including nirsevimab and maternal vaccines, became available in 2023.
  • Understanding factors influencing the uptake of these new preventive measures is crucial.

Purpose of the Study:

  • To investigate the sociodemographic characteristics associated with RSV immunoprophylaxis uptake in infants.
  • To identify factors influencing the intent to receive nirsevimab.
  • To analyze the impact of socioeconomic status and childcare arrangements on RSV prevention.

Main Methods:

  • A cross-sectional survey was conducted among parents of infants under 8 months in Central Pennsylvania.
  • Logistic regression analysis was used to examine sociodemographic factors related to immunoprophylaxis.
  • A sensitivity analysis addressed the nirsevimab shortage during the 2023-2024 RSV season.

Main Results:

  • 66.9% of infants received RSV immunoprophylaxis, and 74.5% intended to receive nirsevimab.
  • Higher income, private insurance, out-of-home childcare, and parental healthcare employment were linked to higher intent for nirsevimab.
  • Enrollment in the Women, Infants, and Children (WIC) program was associated with lower intended nirsevimab receipt.

Conclusions:

  • Sociodemographic factors significantly impact RSV immunoprophylaxis intent and uptake.
  • Parental employment in healthcare was the strongest predictor of nirsevimab intent, suggesting higher health literacy.
  • Out-of-home childcare was the sole predictor of actual RSV immunoprophylaxis uptake, highlighting the need for equitable access policies.
Abstract

Keywords:
health disparitiesimmunizationinfant healthnirsevimabrespiratory syncytial virussocioeconomic status

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