Related Experiment Video
Updated: Jan 13, 2026
04:36
Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen
Published on: January 19, 2024
5.3K
Association Between Antibiotic Exposure and the Risk of Male Infertility: A Case-Control Study
Friday E Okonofua1,2, Lorretta Favour C Ntoimo2,3, Titus A M Msagati4
1Department of Obstetrics and Gynaecology, University of Benin Teaching Hospital, University of Benin, Benin City 300213, Nigeria.
Journal of Xenobiotics
|October 28, 2025
Summary
Antibiotic exposure in Nigeria is linked to male infertility. Specific antibiotics like ampicillin and chloramphenicol negatively impacted sperm quality, while tetracycline showed a positive association in infertile men.
Area of Science:
- Reproductive Health
- Pharmacology
- Environmental Health
Background:
- Irregular antibiotic use is prevalent in Nigeria, contributing to antibiotic resistance.
- Antibiotics have been implicated in declining male fertility in animal studies.
Purpose of the Study:
- To investigate the association between antibiotic exposure and sperm quality in Nigerian men.
- To determine if specific antibiotics correlate with infertility-related sperm characteristics.
Main Methods:
- Prospective case-control study involving 136 infertile and 154 fertile men.
- Semen analysis was performed.
- Liquid Chromatography Mass Spectrometry (LC-MS) assayed urinary antibiotic levels.
Main Results:
- Urinary ampicillin was associated with a significant decline in sperm count among infertile men.
- Urinary chloramphenicol showed significant associations with reduced sperm motility and morphology in infertile cases.
- Urinary tetracycline was independently associated with increased sperm motility in infertile men.
Conclusions:
- Urinary ampicillin, chloramphenicol, and tetracycline may be associated with varying sperm characteristics and overall sperm quality in Nigerian men.
- Findings highlight potential environmental factors impacting male reproductive health in the region.
Related Concept Videos
01:23Infertility in Males
522
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
522
01:41Spermatogenesis
121.6K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
121.6K
01:11Testing a Claim about Mean: Known Population SD
3.2K
A complete procedure of testing the hypothesis about a population mean is explained here.
Estimating a population mean requires the samples to be distributed normally. The data should be collected from the randomly selected samples having no sampling bias. The sample size needed to be higher than 30, and most importantly, the population standard deviation should be already known.
In most realistic situations, the population standard deviation is often unknown, but in rare circumstances, when it...
Estimating a population mean requires the samples to be distributed normally. The data should be collected from the randomly selected samples having no sampling bias. The sample size needed to be higher than 30, and most importantly, the population standard deviation should be already known.
In most realistic situations, the population standard deviation is often unknown, but in rare circumstances, when it...
3.2K
01:26Factors Affecting the Risk of Infection
13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
397
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
397
00:57Antibiotic Selection
59.3K
Overview
59.3K