Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

946
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
946
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Cancer02:18

Cancer

53.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.4K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

11.1K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive flexibility, empathy and social self-efficacy in children with ADHD and their parents: An actor-partner interdependence model.

Acta psychologica·2026
Same author

Dysphagia: A Novel Risk Factor for Poor Outcomes Following Cardiovascular Procedures.

Journal of the American Heart Association·2026
Same author

Clinicopathological characterization of cervical squamous cell carcinoma with <i>PIK3CA</i> hotspot mutation: A single-institution study.

Oncology letters·2026
Same author

Simultaneous CRISPR/Cas9-induced double-strand breaks are lethal in models of pancreatic cancer.

The Journal of clinical investigation·2026
Same author

[Patient and family predictors of group intervention outcomes in children with attention-deficit/hyperactivity disorder: a multidimensional model analysis].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2026
Same author

A mouse model of HPV-associated cervicovaginal carcinosarcoma with comparative analysis to human clinical cases.

Cell & bioscience·2026
Same journal

RETRACTED: Zito Marino et al. AXL and MET Tyrosine Kinase Receptors Co-Expression as a Potential Therapeutic Target in Malignant Pleural Mesothelioma. <i>J. Pers. Med.</i> 2022, <i>12</i>, 1993.

Journal of personalized medicine·2026
Same journal

Correction: Rao et al. Ensemble Deep-Learning-Based Prognostic and Prediction for Recurrence of Sporadic Odontogenic Keratocysts on Hematoxylin and Eosin Stained Pathological Images of Incisional Biopsies. <i>J. Pers. Med.</i> 2022, <i>12</i>, 1220.

Journal of personalized medicine·2026
Same journal

Three-Dimensional Bronchovascular Modelling in Sublobar Pulmonary Resection: A Tool for Personalised Thoracic Surgery.

Journal of personalized medicine·2026
Same journal

Serum Albumin, Globulin and Albumin-Globulin Ratios as Biomarkers of Clinical Outcomes in COVID-19 Pneumonia.

Journal of personalized medicine·2026
Same journal

New Advances and Perspectives in Ophthalmology: Progress and Modern Challenges Toward Personalized Eye Care.

Journal of personalized medicine·2026
Same journal

Bridging Ancestry-Stratified Bias in Pharmacogenomics AI: Toward Metabolomics-Inclusive Multi-Omics Precision Medicine.

Journal of personalized medicine·2026
See all related articles

Related Experiment Video

Updated: Jan 13, 2026

Skin Tattooing As A Novel Approach For DNA Vaccine Delivery
06:37

Skin Tattooing As A Novel Approach For DNA Vaccine Delivery

Published on: October 18, 2012

16.6K

Personalizing DNA Cancer Vaccines.

Annie A Wu1, Kaiqi Peng1, Melanie Vukovich1

  • 1Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Journal of Personalized Medicine
|October 28, 2025
PubMed
Summary
This summary is machine-generated.

Cancer vaccines are evolving, with DNA-based vaccines showing promise for personalized oncology. Advances in sequencing and computational tools enable the identification of tumor-specific neoantigens for tailored cancer immunotherapy.

Keywords:
DNAcancer vaccineclinical trialneoantigenstumor antigens

More Related Videos

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

12.2K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.8K

Related Experiment Videos

Last Updated: Jan 13, 2026

Skin Tattooing As A Novel Approach For DNA Vaccine Delivery
06:37

Skin Tattooing As A Novel Approach For DNA Vaccine Delivery

Published on: October 18, 2012

16.6K
Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

12.2K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.8K

Area of Science:

  • Oncology
  • Immunology
  • Biotechnology

Background:

  • Tumor immunotherapy leverages the immune system against cancer.
  • Vaccines, traditionally for infectious diseases, are now adapted for cancer treatment.
  • Personalized oncology is advancing through novel therapeutic strategies.

Purpose of the Study:

  • To review the role of DNA-based vaccines in cancer immunotherapy.
  • To examine strategies for neoantigen identification and vaccine design.
  • To discuss advances, limitations, and future directions in cancer vaccine development.

Main Methods:

  • Review of preclinical studies and clinical trials.
  • Analysis of advancements in molecular biology and computational tools.
  • Examination of personalized DNA vaccine development processes.

Main Results:

  • DNA-based vaccines are a promising approach for cancer immunotherapy.
  • Improved techniques enhance neoantigen identification and vaccine optimization.
  • Personalized DNA vaccines involve tumor sequencing, computational analysis, and custom production.

Conclusions:

  • Recent advances support the potential of DNA vaccines in personalized oncology.
  • Overcoming current limitations requires addressing clinical and technical challenges.
  • Further research is crucial for the successful implementation of cancer vaccines.