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Updated: Jan 13, 2026

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Possible Drug-Radiopharmaceutical Interaction in 99mTc-Sestamibi Parathyroid Imaging
Tracia-Gay Kennedy-Dixon1, Mellanie-Anne Didier2, Keisha Allen-Dougan1
1Faculty of Medical Sciences, University of the West Indies, Mona Campus, Kingston 7, Jamaica.
Drug interactions with Technetium-99m-methoxyisobutyl isonitrile (99mTc-MIBI) can cause false-negative parathyroid scans. Adjusting medication timing corrected the issue, ensuring accurate diagnosis of primary hyperparathyroidism.
Area of Science:
- Nuclear Medicine
- Pharmacology
Background:
- Drug-radiopharmaceutical interactions can affect radiotracer biodistribution and diagnostic accuracy.
- P-glycoprotein (P-gp) mechanisms are implicated in altered radiotracer uptake.
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