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First Report on Cardiac Troponin T Detection in Canine Amniotic Fluid
Elisa Giussani1, Alessandro Pecile1, Andrea Pasquale Del Carro2
1Department of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, Italy.
Veterinary Sciences
|October 28, 2025
Summary
Cardiac troponin T (cTnT) was detected in all canine amniotic fluid samples at birth. Amniotic cTnT levels correlated with maternal factors and delivery type, suggesting potential diagnostic value in canine neonatology.
Area of Science:
- Veterinary Medicine
- Neonatology
- Cardiology
Background:
- Pregnancy complications can cause fetal hypoxia, leading to cardiac ischemia and troponin release.
- Cardiac troponin T (cTnT) is a biomarker for cardiac injury, typically measured in blood.
- No data exists on cTnT presence or significance in canine amniotic fluid (AF).
Purpose of the Study:
- To determine if cTnT is detectable in canine AF at birth.
- To explore correlations between AF cTnT concentration and maternal/neonatal outcomes.
Main Methods:
- Collected 40 AF samples from 14 bitches during delivery.
- Analyzed AF for canine cTnT using a commercial ELISA kit.
Main Results:
- cTnT was detected in 100% of AF samples.
- Concentrations ranged from 74.1 to 318 ng/L (mean ± SD: 191.6 ± 66.4 ng/L).
- Maternal morphotype, age, weight, parturition type, and puppy expulsion time correlated with AF cTnT levels.
Conclusions:
- cTnT is present in canine AF at birth.
- Amniotic cTnT shows potential as a biomarker in canine neonatology.
- Further research is needed to fully elucidate the clinical role of AF cTnT.
