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Feline Lymphoma in Focus: Examining the Patterns and Types in Croatia's Pathological Records
Vida Eraghi1, Iva Ciprić1, Nikola Serdar1
1Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Veterinary Sciences
|October 28, 2025
Summary
This study reveals feline lymphoma has bimodal age peaks and breed predispositions. Multicentric lymphoma is most common, with T-cell types in mediastinal forms and B-cell types in alimentary/multicentric forms.
Area of Science:
- Veterinary Oncology
- Comparative Pathology
- Feline Neoplasia
Background:
- Feline lymphoma is a prevalent cancer in cats.
- Its development is influenced by complex genetic, immune, environmental, and viral factors.
- Understanding epidemiological and immunophenotypic patterns is crucial for feline cancer research.
Purpose of the Study:
- To conduct a 15-year retrospective analysis of feline lymphoma cases.
- To investigate the epidemiology, anatomical distribution, and immunophenotype of feline lymphoma.
- To identify breed predispositions and correlations with viral infections.
Main Methods:
- Retrospective analysis of feline lymphoma cases (15 years).
- Data collected from the University of Zagreb's Department of Veterinary Pathology.
- Epidemiological, anatomical, and immunophenotypic data were analyzed.
Main Results:
- Bimodal age distribution observed (2-3 years and 10-12 years).
- Multicentric lymphoma was most common, followed by alimentary and mediastinal forms.
- Mediastinal lymphoma correlated with feline leukemia virus/feline immunodeficiency virus (FeLV/FIV) infection and was T-cell predominant; alimentary/multicentric forms were B-cell predominant.
Conclusions:
- Feline lymphoma exhibits diverse epidemiological and immunophenotypic characteristics.
- Breed predispositions (British, European Shorthairs) and viral associations (FeLV/FIV) were identified.
- Findings emphasize the need for individualized diagnostic and therapeutic approaches in feline lymphoma management.
