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Flow-Compensated vs. Monopolar Diffusion Encodings: Differences in Lesion Detectability Regarding Size and Position
Alessandra Moldenhauer1, Frederik B Laun1, Hannes Seuss1,2
1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Maximiliansplatz 3, 91054 Erlangen, Germany.
Tomography (Ann Arbor, Mich.)
|October 28, 2025
Summary
Flow-compensated (FloCo) diffusion-weighted imaging (DWI) detects more liver lesions than monopolar (MP) DWI. FloCo DWI improves sensitivity, especially for small lesions and those in the left liver lobe.
Area of Science:
- Radiology
- Medical Imaging
- Oncology
Background:
- Liver diffusion-weighted imaging (DWI) is susceptible to motion artifacts.
- Flow-compensated (FloCo) DWI reduces cardiac motion artifacts compared to monopolar (MP) DWI.
Purpose of the Study:
- To compare the lesion detection capabilities of FloCo DWI and MP DWI.
- To assess the impact of lesion size and location on detection rates.
Main Methods:
- Forty patients with suspected focal liver lesions (FLLs) underwent both FloCo and MP DWI.
- Lesions were segmented, and detection rates, sensitivity, and contrast-to-noise ratio (CNR) were compared.
Main Results:
- FloCo DWI detected significantly more FLLs than MP DWI (1211 vs. 1154).
- FloCo DWI showed higher sensitivity (96.3% vs. 91.7%) and CNR.
- More additional lesions were detected with FloCo DWI in the left liver lobe.
Conclusions:
- FloCo DWI enhances the detection of FLLs compared to MP DWI.
- Improved detection is particularly notable for small lesions and those in the left liver lobe.
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