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Prognostic Significance of CRP/Albumin, D-Dimer/Albumin, D-Dimer/Fibrinogen Ratios and Triglyceride-Glucose Index in
Nurten Nur Aydın1, Murat Aydın1
1Department of Infectious Diseases and Clinical Microbiology, Erzurum Regional Training and Research Hospital, Erzurum 25080, Turkey.
Insights
New inflammatory markers like CRP/albumin ratio (CAR), D-dimer/albumin ratio (DAR), D-dimer/fibrinogen ratio (DFR), and triglyceride-glucose index (TGI) can predict mortality in Crimean-Congo hemorrhagic fever (CCHF). Higher levels of these markers indicate a poorer prognosis for CCHF patients.
Area of Science:
- Infectious Diseases
- Clinical Medicine
- Biomarkers
Background:
- Crimean-Congo hemorrhagic fever (CCHF) is a severe zoonotic viral illness with a high fatality rate.
- Identifying reliable prognostic indicators for CCHF is crucial for patient management and outcomes.
Purpose of the Study:
- To evaluate the prognostic value of novel inflammatory markers: CRP/albumin ratio (CAR), D-dimer/albumin ratio (DAR), D-dimer/fibrinogen ratio (DFR), and triglyceride-glucose index (TGI) in predicting mortality in CCHF patients.
Main Methods:
- A prospective study involving 76 CCHF patients and 38 healthy controls.
- Collected demographic, clinical, and laboratory data at presentation.
- Analyzed inflammatory markers (CAR, DAR, DFR, TGI) and their correlation with mortality.
Main Results:
- CAR, DAR, DFR, and TGI levels were significantly elevated in CCHF patients compared to controls (p < 0.001).
- These markers were significantly higher in non-survivors versus survivors (p ≤ 0.005).
- DFR and TGI demonstrated the highest predictive power for mortality (AUC: 0.938 and 0.899, respectively).
Conclusions:
- The inflammatory markers CAR, DAR, DFR, and TGI show significant potential as prognostic tools for predicting mortality in CCHF.
- These markers can aid in risk stratification and clinical decision-making for CCHF patients.
Background:
Crimean-Congo hemorrhagic fever (CCHF) is a severe zoonotic viral infection with high mortality rates. This study aimed to examine the prognostic value of new-generation inflammatory markers-CRP/albumin ratio (CAR), D-dimer/albumin ratio (DAR), D-dimer/fibrinogen ratio (DFR), and triglyceride-glucose index (TGI)-in predicting mortality among patients diagnosed with CCHF.
Methods:
This prospective study involved 76 patients with a positive polymerase chain reaction test for CCHF and 38 age- and sex-matched healthy controls between 15 April 2023 and 15 October 2024. Participants' demographic, clinical, and laboratory data at presentation were recorded.
Results:
CAR, DAR, DFR, and TGI levels were significantly higher in the patient group compared to the control group (all p < 0.001). Furthermore, when mortal cases were compared with survivors, all of these markers were found to be significantly higher in the mortal group (p = 0.005, p = 0.004, p = 0.001, and p = 0.003, respectively). In Kaplan-Meier analysis, survival time was significantly shorter in patients with higher levels of these parameters (p < 0.001 for all). In the Receiver Operating Characteristic analysis conducted to differentiate mortal cases from survivors, DFR and TGI were identified as the markers with the highest predictive power (area under the curve: 0.938 and 0.899, respectively).
Conclusions:
Inflammatory markers CAR, DAR, DFR and TGI may serve as significant prognostic tools to predict mortality in CCHF.
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