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TGF-β1 Is Associated with Left Ventricular Dysfunction
Bartosz Rakoczy1, Michal Rac2, Andrzej Krzystolik3
1Department of Clinical Radiology, University Hospital of Karol Marcinkowski, 26 Zyty St., 65-046 Zielona Góra, Poland.
Current Issues in Molecular Biology
|October 28, 2025
Summary
Transforming growth factor-beta 1 (TGF-β1) shows weak links to ventricular dysfunction in early coronary artery disease (CAD). High TGF-β1 is associated with diastolic dysfunction and arrhythmia risk, not heart attacks.
Area of Science:
- Cardiovascular Research
- Biomarkers in Atherosclerosis
- Vascular Biology
Background:
- The role of transforming growth factor-beta 1 (TGF-β1) in atherosclerosis vascular effects is debated.
- Understanding TGF-β1's impact on early coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) is crucial.
Purpose of the Study:
- To investigate correlations between plasma TGF-β1 concentrations and echocardiographic/vascular parameters in early CAD patients.
- To assess TGF-β1's association with risk factors and disease progression in this cohort.
Main Methods:
- Echocardiography and electrocardiography in 100 early CAD patients.
- Doppler ultrasound assessed carotid/brachial artery intima-media thickness, ankle-brachial index, and atherosclerotic plaques.
- Plasma TGF-β1 levels were measured and correlated with clinical and ultrasound findings.
Main Results:
- No significant correlation found between TGF-β1 and diabetes, hypertension, metabolic syndrome, or myocardial infarction.
- Weak associations observed with impaired ventricular function; strong positive correlation with QRS width.
- Significant positive correlations between TGF-β1 and left ventricular diastolic dysfunction and arrhythmia risk were identified.
Conclusions:
- High plasma TGF-β1 is not linked to heart attacks or common risk factors in early CAD, suggesting stable plaques.
- TGF-β1 levels are significantly associated with left ventricular diastolic dysfunction and increased arrhythmia risk in early CAD patients.
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