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Metabolites of Food Bioactives Targeting Post-Translational Modifications in Cardiovascular Diseases: Mechanisms and

Hanya Dong1, Hai Jiang1, Haolin Yang2

  • 1Key Laboratory of Basic and Application Research of Beiyao, (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, China.

Journal of Agricultural and Food Chemistry
|October 28, 2025
PubMed

Insights

Natural products from foods and plants can improve cardiovascular diseases (CVDs) by regulating protein modifications. This research clarifies how these natural compounds target post-translational modifications (PTMs) to treat heart conditions.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) like heart failure (HF), myocardial infarction (MI), and myocardial ischemia reperfusion injury (MIRI) are leading global causes of mortality.
  • Post-translational modifications (PTMs) are crucial regulators of protein function, localization, and interactions within the cardiovascular system, influencing CVD pathogenesis.

Purpose of the Study:

  • To systematically review the mechanisms by which natural products (NPs) and their analogues improve CVDs.
  • To elucidate how NPs regulate PTMs to counteract cardiovascular pathology.
  • To provide a theoretical foundation for developing NP-based therapies targeting PTMs for CVD prevention and treatment.

Main Methods:

  • Literature review and systematic summary of existing research on natural products and their effects on cardiovascular diseases.
  • Analysis of the molecular mechanisms through which various classes of NPs (flavonoids, polyphenols, terpenoids, amides) modulate PTMs.
  • Investigation of the role of metabolite-mediated PTMs in CVD pathological processes.

Main Results:

  • Natural products, including flavonoids, polyphenols, terpenoids, and amides, demonstrate potential in improving CVDs.
  • NPs exert their beneficial effects by regulating the levels and activity of specific PTMs.
  • The study clarifies the direct link between NP intervention, PTM regulation, and the amelioration of CVDs.

Conclusions:

  • Natural products offer a promising therapeutic strategy for cardiovascular diseases by targeting post-translational modifications.
  • Understanding the molecular interplay between NPs and PTMs provides a basis for novel drug development in cardiology.
  • This work highlights the significance of metabolite-mediated PTMs in cardiovascular health and disease management.

Keywords:
acetylationcardiovascular diseasesmitochondrial metabolismnatural productspost-translational modificationssirtuins

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