Related Experiment Video
Updated: Jan 13, 2026
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
Admission plasma levels of fatty acids and kidney function in patients with ST-segment elevation myocardial
Christa Meisinger1, Timo Schmitz1, Philip Raake2
1Epidemiology, Medical Faculty, University of Augsburg, 86156 Augsburg, Germany.
Background:
Prior studies suggested a link between polyunsaturated fatty acids (PUFAs) and the development of chronic kidney disease (glomerular filtration rate [GFR] < 60 ml/min/1.73 m²), but so far there are no studies on the association between PUFAs and kidney function in patients with acute myocardial infarction (AMI). We aimed to investigate whether and how plasma fatty acids levels at admission were associated with kidney function in patients with acute ST-elevation myocardial infarction (STEMI).
Methods:
This study was based on data from 717 patients with STEMI aged 29 to 98 years admitted to the University Hospital Augsburg between May 2009 and July 2013. In arterial blood samples taken from these patients immediately after admission a panel of plasma fatty acids was measured by a high-throughput nuclear magnetic resonance spectroscopy platform (Nightingale Health, Finland). To examine the association between the fatty acid groups (exposure) and kidney function (continuous eGFR; outcome), linear regression models were calculated. P values were FDR-adjusted.
Results:
In multivariable analyses the concentrations of total PUFAs, total omega-6 fatty acids, linoleic acid, and docosahexaenoic acid (DHA) were positively associated with serum eGFR values at admission. These findings were supported by a significantly positive association between these fatty acids in relation to total fatty acids (except for the ratio DHA/total fatty acids). While the concentration of monounsaturated fatty acids (MUFAs) was not associated with eGFR, a significantly inverse association was observed between the ratio MUFAs/total fatty acids and kidney function.
Conclusions:
PUFAs, particularly omega-6 fatty acids, seem to be associated with kidney function in patients with AMI. Given the prognostic importance of renal function in coronary heart disease/AMI patients, further research on interventions to minimize worsening renal function and protect kidney function in this patient group is warranted.
More Related Videos
05:26Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
05:30Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
Published on: January 31, 2025
Related Concept Videos
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
01:22Acute Kidney Injury I: Introduction
01:17Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...