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Updated: Jan 13, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
Short-term complications of immediate implant-based breast reconstruction: Risk factor analyses and a novel
Merel M L Kooijman1, Leonie A E Woerdeman1, Frederieke H van Duijnhoven2
1Department of Plastic and Reconstructive Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Smoking significantly increases risks for complications and implant loss after immediate implant-based breast reconstruction (IBR). A new risk algorithm helps predict outcomes and guide patient decisions for breast cancer surgery.
Area of Science:
- Plastic Surgery
- Oncologic Surgery
- Breast Reconstruction
Background:
- Immediate implant-based breast reconstruction (IBR) following mastectomy carries risks of short-term complications.
- Identifying risk factors is crucial for informed patient decision-making.
Purpose of the Study:
- To analyze risk factors for short-term complications and implant loss after IBR.
- To develop a cumulative risk algorithm for predicting outcomes.
Main Methods:
- Retrospective analysis of 1989 IBRs performed in 1512 women between 2012 and 2019.
- Evaluation of complications requiring re-intervention or implant loss within 16 postoperative weeks.
- Development of a cumulative risk algorithm based on identified factors.
Main Results:
- Short-term complications occurred in 21.3% of IBRs, with 5.3% resulting in implant loss.
- Smoking was the strongest risk factor, increasing complication risk by 2.7-fold and implant loss by 2.3-fold.
- Other significant factors included non-staff surgeon, high specimen/implant weight, comorbidity, and long procedure time.
Conclusions:
- While 21% of breasts required re-intervention, only 5% of implants were lost.
- Smoking is the most critical factor influencing complications and implant loss.
- The developed risk algorithm aids in shared decision-making for IBR.
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