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Updated: Jan 13, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that

Uddalok Jana1, Oscar L Rodriguez2, William Lees1

  • 1Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA.

Cell Genomics
|October 28, 2025
PubMed
Abstract

Keywords:
IGHCIGHC allelesadaptive immunityevolutionary selectiongenetic diversityhaplotype variationimmunoglobulin heavy chain constant regionlong-read sequencingstructural variants

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