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For the first time, German recommendations for diagnosis and treatment of gout on an interdisciplinary S3 guideline level are available. For the diagnosis of a typical gout attack in a primary care setting, the typical clinical picture, medical history, and an elevated serum uric acid level are usually sufficient; gout might be diagnosed with the aid of the so-called gout calculator. For acute joint inflammations not typical of gout, specialist medical professionals may utilize additional diagnostic procedures such as joint sonography, joint aspiration with microscopic crystal detection, and dual-energy computed tomography. Once the diagnosis is confirmed, there are 2 pillars of gout treatment: short-term acute treatment of the attack; and target-oriented, causal uric acid-lowering therapy. Since patients with gout usually suffer from other cardio-metabolic-renal diseases, treatment of these conditions should also be optimized. In addition to recurrent gout inflammation, these diseases ultimately cause a higher rate of cardiovascular events and mortality. Although not primarily approved for gout, the group of SGLT2 inhibitors, due to their uricosuric side effect, represents a possible treatment option for patients with gout and corresponding comorbidities.
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