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Updated: Jun 27, 2026
Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area
Published on: February 2, 2017
Advances in no-reflow after stroke reperfusion therapy
Shen Liu1, Tingting Chen2, Yanbin Li3
1Comprehensive Rehabilitation Department, China Rehabilitation Research Center (Beijing Boai Hospital), Capital Medical University, Beijing, China; Institute for Brain Disorders, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Futility in reperfusion therapy for acute ischemic stroke occurs when successful recanalization fails to improve patient outcomes. Addressing the no-reflow phenomenon is crucial for better stroke treatment results.
Area of Science:
- Neurology
- Vascular Medicine
- Medical Imaging
Background:
- Reperfusion therapy, including IVT and EVT, is standard for acute ischemic stroke.
- Successful reperfusion does not guarantee favorable outcomes in over 50% of patients.
- Futile reperfusion (FR) describes treatment failure despite successful recanalization.
Purpose of the Study:
- To define and explore futile reperfusion (FR) in stroke.
- To investigate the role of the no-reflow phenomenon in FR.
- To review current knowledge on no-reflow, including its mechanisms, diagnosis, predictors, and treatments.
Main Methods:
- Literature review focusing on FR and no-reflow in stroke.
- Analysis of pathophysiological mechanisms and imaging evaluation methods.
- Synthesis of current intervention strategies and research prospects.
Main Results:
- No-reflow is a significant contributor to FR after reperfusion therapy.
- High prevalence of no-reflow exists in stroke patients undergoing reperfusion.
- Lack of standardized imaging diagnostics hinders effective no-reflow treatment.
Conclusions:
- No-reflow is a critical challenge in managing stroke patients post-reperfusion.
- Effective treatments for no-reflow are lacking due to diagnostic limitations.
- Further research is needed to establish diagnostic standards and therapeutic interventions for no-reflow.
