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Management of Bladder Cancer During Pregnancy: A Narrative Review
1Department of Urology, University Hospital of Marche, Ancona, Italy lucio.dellatti@ospedaliriuniti.marche.it.
Anticancer Research
|October 28, 2025
Summary
Bladder cancer (BC) in pregnancy is rare, complicating diagnosis and treatment. Management prioritizes fetal safety, often involving conservative approaches due to risks of radical interventions.
Area of Science:
- Oncology
- Obstetrics & Gynecology
- Urology
Background:
- Bladder cancer (BC) during pregnancy is exceptionally rare, with limited epidemiological data.
- Existing literature primarily comprises isolated case reports, necessitating a comprehensive review.
Purpose of the Study:
- To provide an updated overview of bladder cancer incidence, risk factors, and management in pregnant individuals.
- To synthesize findings from published case reports and literature on this rare condition.
Main Methods:
- A comprehensive literature search was conducted on PubMed, EMBASE, and Google Scholar.
- Keywords included "bladder cancer," "urothelial carcinoma," "pregnancy," and "treatment."
- Eighteen relevant articles were included in the final analysis.
Main Results:
- Pregnancy can complicate BC diagnosis due to overlapping symptoms; persistent hematuria warrants investigation.
- Non-invasive imaging like ultrasound and MRI are preferred diagnostic tools, prioritizing fetal safety.
- Cystoscopy, while the gold standard, presents risks during pregnancy.
Conclusions:
- Treating bladder cancer during pregnancy requires balancing maternal health and fetal safety.
- Gestational age and tumor stage significantly guide treatment decisions.
- Conservative management is often favored over radical interventions to minimize fetal risk.
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