Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

4.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.8K
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

6.2K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
6.2K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

548
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
548
Lipid Absorption01:24

Lipid Absorption

2.4K
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
2.4K
Lipid Catabolism01:25

Lipid Catabolism

841
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
841

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The association of socioeconomic status and response to pediatric health behavior and lifestyle obesity treatment in Germany and Sweden: A multiyear, two-cohort observational study.

PLoS medicine·2026
Same author

Corrigendum to 'Pink adipose tissue: A paradigm of adipose tissue plasticity' [Ann. Endocrinol. 85 (2004) 248-51].

Annales d'endocrinologie·2026
Same author

NR0B1 Gene Variants as Rare Forms of Primary Adrenal Insufficiency in Children: Case Report and Narrative Review.

Genes·2026
Same author

Deciphering the role of adipose tissue microbial DNA in obesity-related metabolic dysfunction.

The Journal of clinical endocrinology and metabolism·2026
Same author

Life expectancy and causes of death in classical laminopathic progeroid syndromes: systematic review with individual-patient data synthesis.

Aging·2026
Same author

The polystyrene beads sign: a simple MRI marker for the preoperative diagnosis of papillary hypothalamic craniopharyngiomas.

European journal of endocrinology·2026

Related Experiment Video

Updated: Jan 13, 2026

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
07:59

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

Published on: July 21, 2017

10.1K

Epidemiological and clinical data from the European Lipodystrophy Registry.

Giovanni Ceccarini1, Camille Vatier2, Baris Akinci3

  • 1Obesity and Lipodystrophy Center, Endocrine Unit, University Hospital of Pisa, Via Paradisa, 2, Pisa 56124, Italy.

European Journal of Endocrinology
|October 28, 2025
PubMed
Summary

The European Consortium of Lipodystrophies registry collected data on 631 patients with rare lipodystrophy syndromes. This largest cohort reveals varied presentations and high rates of metabolic complications, impacting patient lifespan.

Keywords:
adipose tissuechronic complicationsleptinlipodystrophymetabolic diseasesregistry

More Related Videos

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.0K
Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle
11:50

Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle

Published on: June 8, 2022

5.0K

Related Experiment Videos

Last Updated: Jan 13, 2026

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
07:59

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

Published on: July 21, 2017

10.1K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.0K
Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle
11:50

Fiber Type and Subcellular-Specific Analysis of Lipid Droplet Content in Skeletal Muscle

Published on: June 8, 2022

5.0K

Area of Science:

  • Endocrinology
  • Rare Diseases
  • Genetics

Background:

  • Lipodystrophy syndromes are rare genetic or acquired conditions characterized by adipose tissue loss.
  • These disorders necessitate collaborative research due to patient rarity.

Purpose of the Study:

  • To establish and analyze data from the European Consortium of Lipodystrophies (ECLip) international registry.
  • To characterize the epidemiology, clinical presentation, and comorbidities of diverse lipodystrophy subtypes.

Main Methods:

  • Recruitment of 631 patients across 19 centers in 13 countries from December 2017 to November 2023.
  • Analysis of cross-sectional data using descriptive statistics.

Main Results:

  • Familial partial lipodystrophy (FPLD) was the most common subtype (57.4%).
  • Over 70% of patients experienced metabolic complications, including dyslipidemia (59.0%) and diabetes (48.4%).
  • Generalized lipodystrophy forms were associated with significantly earlier mortality (median age 27.0 years) compared to partial forms (median age 72.0 years).

Conclusions:

  • The ECLip registry represents the largest cohort of lipodystrophy patients to date.
  • The findings provide a comprehensive overview of lipodystrophy's epidemiology and clinical impact.
  • Understanding disease characteristics is crucial for managing metabolic complications and improving patient outcomes.