Aggregate index of systemic inflammation as a new prognostic marker in patients with coronary artery disease...

Area of Science:

• Cardiology
• Inflammation Research
• Clinical Outcomes

Background:

• Systemic inflammation plays a role in cardiovascular disease progression.
• Assessing inflammatory markers can aid in predicting outcomes for patients with coronary artery disease (CAD).

Purpose of the Study:

• To evaluate the association between the aggregate index of systemic inflammation (AISI) and long-term outcomes in CAD patients following percutaneous coronary intervention (PCI).

Main Methods:

• A cohort of 3482 CAD patients undergoing PCI was divided into higher (AISI ≥ 366) and lower (AISI < 366) AISI groups.
• Outcomes assessed included all-cause mortality (ACM), cardiac mortality (CM), major adverse cardiovascular events (MACEs), and major adverse cardiovascular and cerebrovascular events (MACCEs).
• Follow-up averaged 37.59 months, with statistical analysis including Cox regression.

Main Results:

• Patients in the higher AISI group exhibited significantly higher incidences of ACM (6.6% vs. 2.6%) and CM (4.1% vs. 1.7%) compared to the lower AISI group (P < 0.001 for both).
• Cox regression analysis revealed that a higher AISI score independently increased the risk of ACM by 2.298 times (HR=2.298) and CM by 2.160 times (HR=2.160).

Conclusions:

• The aggregate index of systemic inflammation (AISI) is an independent predictor of adverse long-term outcomes, including mortality, in patients with coronary artery disease after percutaneous coronary intervention.
• Elevated systemic inflammation, as indicated by AISI, is associated with poorer prognosis in post-PCI patients.