Sperm DNA integrity and sexual dysfunction among infertile men : DFI and sexual dysfunction

Area of Science:

• Reproductive Medicine
• Andrology
• Men's Health

Background:

• Sperm DNA fragmentation (DFI) impacts male fertility.
• Sexual dysfunction (SD) is common in men, affecting quality of life.
• The relationship between DFI and SD requires further investigation.

Purpose of the Study:

• To assess the association between sperm DNA fragmentation index (DFI) and sexual dysfunction (SD).
• To evaluate erectile dysfunction severity using the Sexual Health Inventory for Men (SHIM) and testosterone deficiency symptoms via the Androgen Deficiency in Aging Male (ADAM) questionnaire.
• To identify predictors of sexual function in infertile men.

Main Methods:

• Retrospective cohort study of 703 infertile men (2000-2020).
• Data collected included SHIM and ADAM questionnaires, semen analysis, and DFI testing.
• DFI was categorized as normal (<30%) or abnormal (≥30%). Multivariable regression analyzed predictors of sexual function.

Main Results:

• Abnormal DFI was found in 39% of men.
• Men with abnormal DFI had significantly lower SHIM scores, indicating more severe erectile dysfunction (p=0.02).
• Higher BMI (>30 kg/m²) was associated with reduced intercourse frequency; smoking and positive ADAM scores correlated with worse SHIM scores.

Conclusions:

• Abnormal sperm DNA fragmentation is significantly associated with erectile dysfunction.
• These findings highlight the importance of assessing sexual health in male infertility evaluations.
• Integrating SD assessments can improve patient care and outcomes in andrology clinics.