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Related Concept Videos

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Hypersensitivities01:30

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
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Aeroallergen immunotherapy update: Developments since the third Practice Parameter.

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    Allergy immunotherapy, including subcutaneous and sublingual (SLIT) methods, offers proven treatment for allergic rhinitis and asthma. Sublingual immunotherapy (SLIT) shows comparable efficacy to injections but with improved safety and self-administration convenience.

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    Area of Science:

    • Immunology
    • Allergology
    • Pharmacology

    Background:

    • Allergy immunotherapy is an established treatment for allergic rhinitis and asthma.
    • Significant advancements have occurred in the last 15 years.
    • The practice parameter for allergen immunotherapy has been updated.

    Purpose of the Study:

    • To review new developments in subcutaneous immunotherapy and sublingual immunotherapy (SLIT).
    • To assess new evidence on the efficacy and safety of allergy immunotherapy.
    • To identify unmet needs and future research directions.

    Main Methods:

    • Review of recent scientific literature.
    • Analysis of evidence from large double-blind placebo-controlled trials.
    • Examination of risk factors and mitigation strategies for anaphylaxis.

    Main Results:

    • Sublingual immunotherapy (SLIT) tablets have demonstrated efficacy and safety in allergic rhinitis, asthma, and atopic dermatitis.
    • Evidence highlights risk factors for anaphylaxis with subcutaneous injections.
    • Approaches to mitigate anaphylaxis risk have been identified.

    Conclusions:

    • Two primary allergy immunotherapy modalities exist: SLIT and subcutaneous immunotherapy.
    • Both methods exhibit similar efficacy.
    • SLIT possesses a superior safety profile and allows for self-administration.