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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

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Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

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Transcriptomic and Clinical Profiling Reveals LGALS3 as a Prognostic Oncogene in Pancreatic Cancer.

Grazia Scuderi¹, Sanja Mijatovic², Danijela Maksimovic-Ivanic²

¹Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.

|October 29, 2025

Summary

Galectin-3 (Gal-3) influences cancer cell growth and survival. High Gal-3 levels correlate with poorer outcomes in several cancers, suggesting its potential as a prognostic biomarker and therapeutic target.

Keywords:

LGALS3 galectins prognostic biomarker transcriptomics

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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Area of Science:

Oncology
Molecular Biology
Genomics

Background:

Galectin-3 (Gal-3) is a protein involved in various cancer processes.
Its precise roles and prognostic value across different cancer types are not fully understood.

Purpose of the Study:

To investigate the effects of LGALS3 gene deletion on cancer transcriptomes.
To evaluate the clinical significance of Gal-3 expression in pan-cancer survival.

Main Methods:

Analyzed CRISPR-Cas9 knockout transcriptomic data to identify gene signatures of LGALS3 loss.
Performed pan-cancer survival analyses using TIMER2.0.
Assessed Gal-3 protein levels and conducted functional studies in pancreatic ductal adenocarcinoma (PDAC).

Main Results:

LGALS3 deletion impacted pathways related to cell division, stress, and neural development.
Elevated LGALS3 expression correlated with worse survival in glioma, PDAC, uveal melanoma, and kidney cancer.
LGALS3 knockout affected cell shape and proliferation in PDAC models.

Conclusions:

Galectin-3 is a significant regulator of cancer progression.
Gal-3 shows potential as a prognostic biomarker and therapeutic target in PDAC and other cancers.