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Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

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Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
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Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

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Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
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Veins01:17

Veins

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Veins are an integral part of our circulatory system, serving as the blood vessels that transport blood from all body regions to the heart. They are a network of hollow tubes that carry blood low in oxygen from the body's cells back to the heart for reoxygenation. Veins are crucial for maintaining the body's overall fluid balance and the continuous circulation of blood.
Structure of Veins:
The structure of veins is specifically designed to assist in the low-pressure transportation of...
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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

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The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
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Veins of Lower Limbs01:15

Veins of Lower Limbs

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The human body consists of an intricate network of veins responsible for the crucial task of blood drainage from the lower limbs. These veins can be categorized into two main types: deep veins and superficial veins.
Formed by the union of the medial and lateral plantar veins, the posterior tibial vein, rising through the calf muscle, assimilates the fibular vein. The anterior tibial vein, a superior extension of the foot's dorsalis pedis vein, merges with the posterior tibial vein at the...
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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Related Experiment Video

Updated: Jan 13, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
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Sex-Specific Gene Expression Differences in Varicose Veins.

Mariya A Smetanina1,2, Valeria A Korolenya1,3, Ksenia S Sevostyanova4,5,6

  • 1Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM) SB RAS, Novosibirsk 630090, Russia.

Biomedicines
|October 29, 2025
PubMed
Summary

Sex influences gene expression in varicose veins (VVs), impacting vein wall remodeling. This study reveals sex-specific gene regulation, offering insights into VV development and potential targeted treatments.

Keywords:
chronic venous diseasegene expressionsex differencesvaricose veins

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Area of Science:

  • Vascular Biology
  • Genomics
  • Sex Differences in Medicine

Background:

  • Varicose veins (VVs) show higher prevalence in women, necessitating research into sex-specific factors.
  • Understanding sex differences in gene expression is crucial for developing tailored healthcare strategies for VVs.

Purpose of the Study:

  • To investigate how biological sex influences gene expression profiles in the vein wall during varicose transformation.
  • To identify specific genes and regulatory mechanisms affected by sex in the pathogenesis of VVs.

Main Methods:

  • Gene expression analysis using reverse transcription quantitative polymerase chain reaction (RT-qPCR) on paired varicose vein (VV) and non-varicose vein (NV) samples.
  • Multiple linear regression (MLR) analysis to assess the predictive value of sex and other patient characteristics on gene expression levels.
  • Identification of potential sex hormone receptor binding sites in regulatory regions of differentially expressed genes.

Main Results:

  • Validated differential expression of 23 genes in VVs.
  • Sex was a moderate predictor for STK38L expression in VVs (higher in women) and EBF1 expression in NVs (lower in women).
  • Sex was a strong predictor for TIMP1 expression in VVs (lower in women), indicating significant sex-specific regulation.

Conclusions:

  • Differential gene expression in VVs suggests involvement in vein wall remodeling.
  • Sex-specific gene expression patterns point towards hormonal regulation and other mechanisms in VV pathogenesis.
  • Findings enhance understanding of sex-related VV development and may inform future therapeutic strategies.