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Updated: Jan 13, 2026

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Regional Brain Volume Changes Across Adulthood: A Multi-Cohort Study Using MRI Data.

Jae Hyuk Shim1, Hyeon-Man Baek1,2, Jung Hoon3

  • 1MTech Lab Co., Ltd., Room B1027, 119, Songdo Munhwa-ro, Yeonsu-gu, Incheon 21985, Republic of Korea.

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Summary
This summary is machine-generated.

Brain structure changes with age, with significant expansion in ventricles and shrinkage in frontal and parietal lobes. This provides a reference for normal aging versus disease.

Keywords:
MRIbrain agingneurodegenerationneuroimagingstructural changesvolumetric analysis

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Area of Science:

  • Neuroimaging
  • Brain Aging
  • Cognitive Neuroscience

Background:

  • Age-related brain structural changes are crucial for understanding cognitive aging and neurodegenerative diseases.
  • Characterizing normative brain volumetric changes across adulthood is essential for identifying deviations from healthy aging.

Purpose of the Study:

  • To comprehensively map age-related volumetric changes in 95 brain regions across adulthood (ages 21-90).
  • To integrate diverse MRI datasets (Korean, IXI, ADNI) for a robust characterization of normative brain aging.

Main Methods:

  • Utilized an optimized neuroimaging pipeline with advanced preprocessing and neural network segmentation on T1-weighted MRI from 1833 cognitively healthy individuals.
  • Analyzed volumetric data across seven age bins, validating pipeline reliability against FreeSurfer (mean ICC: 0.9965).
  • Corrected for sex and cohort effects, then computed percentage changes in bilateral brain volumes across the lifespan.

Main Results:

  • Observed significant volumetric expansion in white matter hypointensities (122.6%) and lateral ventricles (115.9%).
  • Documented moderate-to-notable shrinkage in frontal (pars triangularis: 21.5%), parietal (inferior parietal: 20.4%), temporal (transverse temporal: 21.6%), and cingulate cortex (16.1%).
  • Found minimal volume changes in the insula (3.7%) and pallidum (2.6%).

Conclusions:

  • This study provides a comprehensive reference for normative regional brain volume changes throughout adulthood.
  • Highlights substantial inter-regional variability in age-related brain volume alterations.
  • Offers a foundation for distinguishing normal aging from early pathological changes in the brain.