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Role of MRI-Based Radiomics in Sinonasal Cancer Management: A Scoping Review
Andrea Migliorelli1, Marianna Manuelli1, Andrea Ciorba1
1ENT & Audiology Unit, Department of Neurosciences, University Hospital of Ferrara, 44100 Ferrara, Italy.
Abstract:
Background/Objectives: Malignant tumors of the sinonasal tract are rare, accounting for approximately 3-5% of all head and neck tumors. Despite recent advances in therapy, overall survival in sinonasal cancer remains limited, with local recurrence representing the leading cause of treatment failure. Consequently, the preoperative identification of patients at higher risk of recurrence or developing more aggressive tumors is of critical importance to guide treatment strategies and improve outcomes. The aim of this review is to analyze the results of the most recent literature studying the use of radiomics in malignant sinonasal tumors. Methods: A comprehensive literature review was conducted using the PubMed/MEDLINE, EMBASE and Cochrane Library databases, in accordance with the PRISMA review criteria (from 2020 to July 2025). Results: The final analysis comprised a total of five articles and 629 patients. At present, radiomics in sinonasal cancer is mainly applied to the prediction of Ki-67 expression, the early assessment of recurrence risk, and the evaluation of response to induction chemotherapy. Conclusions: The results of this review indicate that radiomics has the potential to play an important role in the management of sinonasal malignant tumors. However, further research is necessary to confirm these findings.
Insights
Radiomics shows promise in predicting outcomes for malignant sinonasal tumors. This technique may help identify patients at high risk for recurrence, guiding personalized treatment strategies.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Malignant sinonasal tumors are rare head and neck cancers with limited survival rates.
- Local recurrence is a primary cause of treatment failure in sinonasal cancer.
- Preoperative risk stratification is crucial for optimizing treatment strategies.
Purpose of the Study:
- To review recent literature on radiomics applications in malignant sinonasal tumors.
- To assess the potential of radiomics in improving patient outcomes.
Main Methods:
- Comprehensive literature review adhering to PRISMA criteria.
- Searched PubMed/MEDLINE, EMBASE, and Cochrane Library databases.
- Included studies published from 2020 to July 2025.
Main Results:
- Analysis of five articles involving 629 patients.
- Radiomics is currently used for Ki-67 expression prediction.
- Applications include early recurrence risk assessment and chemotherapy response evaluation.
Conclusions:
- Radiomics demonstrates potential in managing malignant sinonasal tumors.
- Further research is needed to validate these findings and clinical utility.
