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Updated: Jan 13, 2026

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
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14-Deoxy-11,12-didehydroandrographolide Alleviates IL-1β-Induced Insulin Resistance by Modulating NOX2-Driven ROS

Chih-Ching Yen1, Chia-Wen Lo2, Jyun-Lin Lee3

  • 1Department of Internal Medicine, China Medical University Hospital, Taichung 404328, Taiwan.

Antioxidants (Basel, Switzerland)
|October 29, 2025
PubMed
Summary

14-Deoxy-11,12-didehydroandrographolide (deAND) combats insulin resistance (IR) by reducing oxidative stress and restoring insulin signaling pathways. This natural compound shows promise for treating obesity-related IR and type 2 diabetes mellitus.

Keywords:
14-Deoxy-11,12-didehydroandrographolide (deAND)3T3-L1 adipocytesIL-1βinsulin resistance (IR)network pharmacologyreactive oxygen species (ROS)

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