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Related Experiment Video

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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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Red-Wine Gene Networks Linked to Exceptional Longevity in Humans.

Patricia Lacayo1, Alexandria Martignoni1, Kenneth Park1

  • 1Department of Foundational Biomedical Sciences, College of Osteopathic Medicine, Touro University California, Vallejo, CA 94592, USA.

Biomolecules
|October 29, 2025
PubMed
Summary

Moderate red wine consumption may promote healthy aging and longevity by influencing genes related to stress response and disease protection. This study identifies 43 key genes linked to red wine and centenarians, suggesting potential health benefits.

Keywords:
agingalcoholalternative medicinecatechinscentenariangallic acidhormesislongevitypolymorphismpolyphenolred wineresveratrolrotundone

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Area of Science:

  • Genetics and Aging Research
  • Nutrigenomics
  • Molecular Biology

Background:

  • Moderate red wine intake is linked to cardiovascular benefits and healthy aging.
  • The genetic underpinnings of red wine's health benefits, particularly for longevity, are not well understood.
  • Centenarians serve as valuable models for exceptional longevity.

Purpose of the Study:

  • To identify and validate genes associated with both moderate red wine consumption and exceptional longevity (centenarians).
  • To explore the functional roles and biological pathways of these identified genes.
  • To investigate the potential protective associations of these genes against major diseases.

Main Methods:

  • Literature analysis across over 190 databases to curate a gene set.
  • Identification of 43 genes intersecting red wine and centenarian-related genes.
  • Gene set enrichment analysis and disease-gene enrichment analysis.

Main Results:

  • A curated list of 43 genes associated with red wine and centenarians was identified.
  • These genes are crucial for stress response and apoptosis, and enriched in pathways like smooth muscle cell proliferation and neuroinflammation.
  • Significant tissue distribution in gastrointestinal, cardiovascular, and respiratory systems was observed.
  • Gene enrichment analysis revealed associations with cardiovascular disease, type 2 diabetes, and cancer.

Conclusions:

  • The identified genes play a role in cellular survival and renewal, potentially offering protection against major causes of mortality.
  • Moderate red wine consumption, particularly for adults over 40, may confer health benefits through hormesis.
  • This study provides a foundational genetic overview of red wine's potential contribution to healthy aging and longevity.