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Curcumin Alleviates Doxorubicin-Induced Cardiotoxicity by Modulating Apelin Expression.

Baris Akca1, Olcay Murat Disli1, Nevzat Erdil1

  • 1Department of Cardiovascular Surgery, Faculty of Medicine, Inonu University, 44280 Malatya, Türkiye.

Biomolecules
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

Curcumin protects against Doxorubicin (Dox)-induced cardiotoxicity by modulating Apelin expression. This study highlights Apelin as a key mediator in Dox cardiotoxicity, suggesting curcumin as a potential cardioprotective adjunct therapy.

Keywords:
anthracycline toxicityapelinergic signalingcardioprotectionheart failureoxidative stress

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Area of Science:

  • Cardiology
  • Pharmacology
  • Biochemistry

Background:

  • Doxorubicin (Dox) cardiotoxicity is a major dose-limiting side effect.
  • Preventive strategies are crucial for managing Dox-induced cardiac failure.
  • Curcumin's antioxidant properties and effect on Apelin were investigated for cardioprotection.

Purpose of the Study:

  • To evaluate curcumin's protective effect against Dox-induced cardiotoxicity.
  • To assess curcumin's impact on Apelin expression in the context of Dox cardiotoxicity.
  • To explore Apelin as a mediator in Dox-induced cardiac dysfunction.

Main Methods:

  • Wistar albino rats were divided into Control, DOX, CUR, and CUR+DOX groups.
  • Doxorubicin (20 mg/kg) was administered intraperitoneally; curcumin (100 mg/kg) was given orally for 14 days prior.
  • Cardiac function markers, biochemical assays, gene expression (Apelin, NF-κB), and histopathology were analyzed.

Main Results:

  • Doxorubicin induced prolonged QT interval, elevated cardiac troponin, oxidative stress (↓SOD, ↑MDA), and decreased Apelin expression.
  • Histopathology revealed degenerative changes and increased iNOS/nitrotyrosine in the DOX group.
  • Curcumin treatment (CUR+DOX) reversed many Dox-induced changes, significantly increasing Apelin and decreasing NF-κB expression.

Conclusions:

  • Apelin is a significant mediator in Doxorubicin cardiotoxicity and a potential therapeutic target.
  • Curcumin demonstrates cardioprotective effects against Dox-induced damage, potentially via regulating Apelin.
  • Curcumin may serve as an adjunct therapy for preventing Doxorubicin-related cardiomyopathies.