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Updated: Jan 13, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

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The Clinical Implications of Progesterone in Preeclampsia

Zhenzhen Liu1,2, Weirong Gu1

  • 1Key Lab of Reproduction and Development, Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.

Biomolecules
|October 29, 2025
PubMed

Insights

Progesterone (P4) is crucial for pregnancy maintenance and may play a role in preeclampsia development and prevention. This review examines progesterone

Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Endocrinology
  • Maternal-Fetal Medicine

Background:

  • Preeclampsia is a major global health concern impacting maternal and neonatal outcomes.
  • Progesterone (P4) is a vital steroid hormone essential for pregnancy maintenance.
  • Emerging evidence links P4 to preeclampsia pathogenesis and prevention.

Purpose of the Study:

  • To review the physiological roles of progesterone in pregnancy.
  • To explore the pathological functions of progesterone in preeclampsia.
  • To assess the clinical applications of progesterone for preeclampsia prevention and treatment.

Main Methods:

  • Literature review of studies on progesterone and preeclampsia.
  • Analysis of physiological and pathological roles of P4.
  • Evaluation of clinical evidence for P4 in preeclampsia management.

Main Results:

  • Progesterone influences vascular function, immune responses, and placental function relevant to preeclampsia.
  • Enzymes and metabolites in P4 synthesis/metabolism are associated with preeclampsia.
  • Clinical application of P4 shows potential but requires further validation.

Conclusions:

  • Progesterone has significant implications in preeclampsia pathogenesis and potential therapeutic applications.
  • Further research is needed to optimize clinical use of progesterone for preeclampsia.
  • This review provides evidence for future research and clinical practice regarding P4 in preeclampsia.

Keywords:
clinical applicationimmune responseplacental functionpreeclampsiaprogesteronevascular function

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